Calcium dobesilate for prevention of gentamicin induced nephrotoxicity in rats mostafa jafarey,1 saeed changizi ashtiyani,2 houshang najafi3 introduction. Calcium dobesilate is an antioxidant drug and this study is aimed to investigate the effects of calcium dobesilate on gentamicininduced nephrotoxicity. The current study aimed to explore the antioxidant and protective effects of pimpinella anisum p. However, nephrotoxicity is one of the complications of its use. Those two properties are likely to prevent methotrexate induced nephrotoxicity. Preliminary toxicity study to determine the volume of gasoline that could cause toxicity was carried out using 56 healthy male albino rats. The plant extract of rhazya stricta has been noted to dosedependently increase the superoxide dismutase activity and the reducedform of glutathione and subsequently decrease lipid peroxides in the renal cortex of gentamicin administered rats. Druginduced nephrotoxicity refers to kidney damage induced by medication administered for the purpose of diagnosing or treating another medical disorder. Original article renoprotective effects of naringenin and. Jul 27, 2015 the renal proximal tubule is a main target for drug induced toxicity. There are some known risk factors for nephrotoxicity.
The present study evaluated gentamicin nephrotoxicity in saffron treated rats. And although drug induced nephrotoxicity may occur in dogs of any age, older dogs are more susceptible. Effect of morin against gentamicin induced nephrotoxicity in young male rats hala a. Wistar rats proved more susceptible to the development of taainduced alf compared with lewis rats. Nephrotoxicity induced by gentamicin has been found to be a complex phenomenon characterized by an. Nephrotoxicity is a significant adverse side effect of gentamicin. Hyperbaric oxygen treatment and nephrotoxicity induced by. Comparative nephrotoxicity of aminoglycoside antibiotics. Oct 23, 2012 gentamicin, an important aminoglycoside, is used to treat many types of bacterial infections, particularly those caused by gramnegative organisms.
The effects of sex hormones on gm induced nephrotoxicity in gonadectomized rats were investigated. A number of crude herbal extracts have been reported to ameliorate gentamicin induced nephrotoxicity. In the present study, we examined effect of oleuropein on the paraoxonase 1 pon1 activity, lipid peroxidation, lipid profile, atherogenic indexes, and relationship of pon1 activity by highdensity lipoproteincholesterol hdlc and atherogenic indices in gentamicin gm induced nephrotoxicity in rats. Mar 31, 2015 molecular mechanism of drug induced nephrotoxicity 1. Nephrotoxicity associated with exposure to chemicals. Gentamicininduced nephrotoxicity 585 gentamicin for 8 days, mgkg fig. Nephrotoxic effects of aminoglycosides on the developing. Wistar rats proved more susceptible to the development of taa induced alf compared with lewis rats. Melatonin ameliorates the drug induced nephrotoxicity.
In addition to causing aki, chronic drug toxicity can, in some cases, lead to ckd and eventual endstage renal disease. Effect of crocus sativus on gentamicin induced nephrotoxicity scielo. The rats were randomly assigned to either the gentamicin injection without garlic supplementation group group i, n 8, genta. In this study we investigated the role of free radicals in gentamicin. Nephrotoxicity was induced in rat by administering single dose of paracetamol 750 mgkg. Ginkgo biloba extract ameriorates gentamicininduced nephrotoxicity in rats. List of animal models for arf in an experimental laboratory s. Gentamicin gm is a widely used antibacterial antibiotic however its optimal clinical benefit is limited by its serious nephrotoxicity and ototoxicity. Curcumin ameliorates methotrexateinduced nephrotoxicity in rats. The aim of this study was to investigate the effects of nicotinamide nad, an antioxidant agent, against nephrotoxicity induced by doxorubicin dxr. Although aminoglycoside induced nephrotoxicity has been the subject of multiple studies, the short and longterm effect of aminoglycosides administration on the developing kidney of the fetus or premature newborn has not yet been determined. We found that the optimal dose for alf induction in rats is 350 mg.
Patients at highest risk of druginduced nephrotoxicity are those with one or more of the following. Effect of pomegranate seed oil against gentamicin induced. Effect of superoxide dismutase treatment on gentamicin nephrotoxicity in rats. Animal models dose, route and duration references 1 glycerol single dose 810 mlkg, im is used for induction of arf single dose 8 mgkg, im is. The aim of present study was evaluating the effect of cimetidine on gentamicinlosartan nephrotoxicity in rats. The aim of the present study was to evaluate the protective effect of crocin against gentamicin induced nephrotoxicity in rats. Oxidative stress plays a key role in leadinduced nephrotoxicity. Free radicals play an important role in the renal injury induced by gentamicin kadkhodaee et al. Efficacy of curcumin on lead induced nephrotoxicity in female. Drugs can also interfere with normal transport mechanisms in the kidney, leading to a variety of electrolyte and acidbase disorders. Cox inhibition and gentamicin nephrotoxicity brazilian journal of medical and biological research 2004 37. Rats administered with gentamycin daily at 80 mgkg ip, for 9 days showed an significant increase in serum urea, serum creatinine and blood urea nitrogen and histopathological examination of kidney revealed extensive proximal tubular necrosis with marked.
Olive leaf extract ole has been demonstrated to have antioxidant and antiinflammatory. Abstract the present study was carried out to determine the severe hepatotoxicity and nephrotoxicity of gasoline on liver, kidney, hematological and oxidative stress parameters in wistar male albino rats. Contrastinduced nephropathy is most commonly defined as acute renal failure occurring within 48 hr of exposure to intravascular radiographic contrast material that is not attributable to other causes. An external file that holds a picture, illustration, etc. Biochemical effects of oleuropein in gentamicininduced.
Gentamicin gm is one of the commonest causes of drug. Simvastatin attenuates chromiuminduced nephrotoxicity in rats. Recently, it has been shown that eryngium caucasicum can act as a free radical scavenger liao et al. Oleuropein is a natural antioxidant and scavenging free radicals. Efficacy of curcumin on lead induced nephrotoxicity in. Abstract gentamicin is an aminoglycoside antibiotic commonly administrated to patients with gram. Material and methods eighty healthy adult male spraguedawley. Gentamicin gm induced nephrotoxicity may be sex hormones related. However, all agents also carry adverse drug effect profiles. Thirty two male wistar rats received gentamicin 100 mgkg, ip, with or without crocin 100 mgkg, ip for seven consecutive days. The protective effect of nigella sativa against cisplatin. The present study was aimed to investigate the influence of thymoquinone tq, a compound isolated from nigella sativa plant with predominant antioxidant property on a rat model of gm induced nephrotoxicity. Gentamicin, at doses of 50 or 100 mgkg body wt administered daily to healthy male mf1 mice by i. Gentamicin is a member of aminoglycosides, which has represented highly effective antimicrobial agents especially in gramnegative infections despite their toxic effects in the kidney.
Severe hepatotoxicity and nephrotoxicity of gasoline petrol. Druginduced impairment of renal function george sunny pazhayattil, anushree c shirali section of nephrology, yale university school of medicine, new haven, ct, usa abstract. Effect of morin against gentamicininduced nephrotoxicity in young male rats hala a. Protective effect of avenanthramides against cisplatin induced. Original article, report by advances in environmental biology. Owing to the poor sensitivity and specificity of serum creatinine scr and blood urea nitrogen bun, new biomarkers for. Drug induced nephrotoxicity refers to kidney damage induced by medication administered for the purpose of diagnosing or treating another medical disorder.
Prevention of methotrexateinduced nephrotoxicity by concomitant administration of garlic aqueous extract in rat. Effect of cimetidine on gentamicinlosartan induced. Pharmaceutical agents provide diagnostic and therapeutic utility that are central to patient care. A control group saline, group 1, n 6 was compared with rats administrated gentamaicin by intrapritoneal injection, at dose rate of 80 mgkg, once daily for 7 days group 2, 3 and 4. Hyperbaric oxygen treatment and nephrotoxicity induced by gentamicin in rats matitiahu berkovitch1,2, yossi shain1,2, eran kozer1,2, michael goldman1,2 and ibrahim abukishk1,2 abstract background.
The rats were divided into control, nad alone, doxorubicin 20 mgkg, i. Ideally, the impairment of renal function should be measured by serial creatinine clearance, but because this step may be neither practical nor costeffective in many centers, most of the. Calcium dobesilate for prevention of gentamicininduced. Although usually reversible, aminoglycosideinduced renal injury prolongs hospitalization time and increase patients cost. Comparative nephrotoxicity of aminoglycoside antibiotics in rats. Even more important, the occurrence of nephrotoxicity is associated with higher patient mortality. Simv decreased mda values and increased gsh levels in cr vitreated rats.
Structural latency of lysosomal nacetyl3glucosaminidasefollowing gentamicin treatment mean of four independent experiments sem. Although aminoglycosideinduced nephrotoxicity has been the subject of multiple studies, the short and longterm effect of aminoglycosides administration on the developing kidney of the fetus or premature newborn has not yet been determined. Inhibitory effect of olive leaf extract on gentamicininduced. Second, we examined whether wistar and lewis rats exhibit any differences in the course of alf induced by different taa doses. Selected parameters of clinical pathology were measured and the kidney were evaluated by histopathology. To evaluate the nephroprotective effect of trichosanthes dioica roxb. The present study was aimed to investigate the influence of thymoquinone tq, a compound isolated from nigella sativa plant with predominant antioxidant property on a rat model of gminduced nephrotoxicity. The degree of nephroprotective activity was measured by. As explained, oxidative stress and inflammation are two factors contributing to gentamicininduced nephrotoxicity and regarding the antioxidant and. In the present study, we examined effect of oleuropein on the paraoxonase 1 pon1 activity, lipid peroxidation, lipid profile, atherogenic indexes, and relationship of pon1 activity by highdensity lipoproteincholesterol hdlc and atherogenic indices in gentamicin gminduced nephrotoxicity in rats. Attenuation of gentamicininduced nephrotoxicity in rats by. Severe hepatotoxicity and nephrotoxicity of gasoline. Effect of study drugs on bun and serum creatinine in a rat model of gentamicininduced nephrotoxicity effect on renal mda and gsh levels figures figures1 1 and and2 2 represent the kidney mda and gsh levels, respectively, in the rat kidneys on day 11. Inhibitory effects of cinnamon extract on gentamicin induced nephrotoxicity in mail adult wistar rats.
Therefore, the present study aimed to compare the renoprotective effects of naringenin and olive oil against cyclosporineinduced nephrotoxicity in rats, focusing on renal dysfunction and damage, as well as antioxidant properties. Effect of morin against gentamicininduced nephrotoxicity in. Effect of morin against gentamicininduced nephrotoxicity. The cessation of the treatment allows a recovery to control values within approximately 8 days. Aug 02, 2017 in the present study, microarray chips were used to analyze the changes in the gene expression profile using a rat model of gentamicin. In the current study, the effects of the administration of aqueousethanolic extract of n. Research article open access hyperbaric oxygen treatment and nephrotoxicity induced by gentamicin in rats matitiahu berkovitch1,2, yossi shain1,2, eran kozer1,2, michael goldman1,2 and ibrahim abukishk1,2 abstract background. Nephrotoxic effects of aminoglycosides on the developing kidney. Effect of cyclooxygenase inhibitors on gentamicininduced nephrotoxicity in rats. Gentamicin sulphate nephrotoxicity seems to be attributed to the generation of reactive oxygen species.
Rapid diagnosis is vital to preserve renal function and to slow down renal injury. Protective effect of bauhinia purpurea on gentamicin induced. Protective effect of avenanthramides against cisplatin induced nephrotoxicity in rats. Rjpt protective effect of butea monospermia flowers.
Pdf gentamicin induced nephrotoxicity in albino mice. Nephrotoxicity is one of the important side effects of anthracycline antibiotics. Inhibitory effect of olive leaf extract on gentamicin. Protective effect of zingiber officinale on gentamicin.
Inhibitory effect of olive leaf extract on gentamicin induced nephrotoxicity in rats majid tavafi, 1 hasan ahmadvand, 2 pooran toolabi 3 introduction. Full text druginduced impairment of renal function ijnrd. Affymetrix genechip microarrays were used for gene expression analysis of the kidneys. Thirty mature female albino rats 190 225 g were randomly divided into five equal groups, first and second. International journal of therapeutic applications, volume 27, 2015, 1622 16 abrogation of cisplatininduced nephrotoxicity in rats by lycopene through ameliorating oxidative stress, inflammation and apoptosis elsayed m. This is a pdf file of an unedited manuscript that has been accepted for. Renal vulnerability to drug toxicity nephrology selfassessment program vol 9, no 4, july 2010 clin j am soc nephrol 4. Abdelhamid department of pharmacology, and department of pathology faculty of medicine, assiut university abstract gentamicin gent which is a commonly used antibiotic causes nephrotoxicity in man and animals. Inhibitory effects of cinnamon extract on gentamicininduced.
For this purpose female spraguedawley rats were given intraperitoneally either gentamicin sulphate 40 mgkg, melatonin 10 mgkg, gentamicin plus melatonin or vehicle control twice. Inhibitory effect of olive leaf extract on gentamicininduced nephrotoxicity in rats majid tavafi, 1 hasan ahmadvand, 2 pooran toolabi 3 introduction. Calcium dobesilate is an antioxidant drug and this study is aimed to investigate the effects of calcium dobesilate on gentamicin induced nephrotoxicity. The prediction of proximal tubular toxicity during drug development remains difficult. Extract against gentamicininduced nephrotoxicity in rats moustafa m. Protective effect of crocin on gentamicininduced nephrotoxicity in rats. K4 1assistant professor, vijaya college of pharmacy, munaganoor, ranga reddy dist, andhra pradesh,india505511 2mother theresa post graduate and research institute of health sciences, gorimedu, puducherry, india. Prevention of methotrexateinduced nephrotoxicity by. The aim of the present study is to clarify the possible corrective role of curcumin on the nephrotoxicity induced by lead acetate. International journal of therapeutic applications issn. The results suggested that curcumin had ameliorated the histopathological and biochemical indices of nephrotoxicity in rats. Moreover, oxidative stress plays an important role in gentamicin. While most of these are clinically insignificant, some drugs.
Methotrexate mtx has been widely used for treatment of cancer and rheumatoid arthritis, but its use has been limited by its nephrotoxicity. Calcium dobesilate for prevention of gentamicininduced nephrotoxicity in rats mostafa jafarey,1 saeed changizi ashtiyani,2 houshang najafi3 introduction. On the other hand, curcumin, a naturally occurring polyphenolic compound, is reported to have antioxidant and antiinflammatory properties. Morin, a bioflavonoid with antioxidant properties, is a constituent of many herbs and fruits that are used as herbal medicines. Effect of dimethyl sulfoxide on gentamicin induced nephrotoxicity in rats. And although druginduced nephrotoxicity may occur in dogs of any age, older dogs are more susceptible. This study investigates the effect of pomegranate seed oil pso on gentamicin induced nephrotoxicity in adult male rats.
Rates of creatinine clearance ccr, pathological scores, and concentrations of drug pgg in the kidneys of rats 15 days after injection with various regimens at low, middle, or high doses. Protective effect of oleanolic acid on gentamicin induced. Effect of cyclooxygenase inhibitors on gentamicininduced. The renal proximal tubule is a main target for druginduced toxicity. Twenty four healthy male wistar rats, weighing between 220 260grams, were divided into three groups. Male wistar rats 200250g were treated with saffron 40 or 80 mgkd for 10 days. Thymoquinone supplementation protects against gentamicin. Pdf histopathological evaluation of nephroprotective. Prediction of druginduced nephrotoxicity and injury. Acrylamide induced acute nephrotoxicity in rats keivan jmahidi department of pathology, faculty of veterinary science, islamic azad university, garmsar branch, garmsar, iran abstract acrylamide acr has been shown to cause neurotoxic effects in humans and neurotoxic, genotoxic, reproductive, and carcinogenic effects in laboratory animals. The group of rats with the higher doses of gentamicin showed a more severe level of histopathological changes, however, bun and creatinine levels were not significantly different p 0. Patients at highest risk of drug induced nephrotoxicity are those with one or more of the following.
Environmental issues aminoglycosides antioxidants antioxidants nutrients cinnamon health aspects laboratory rats materia medica, vegetable plant extracts rats as laboratory animals toxicity research urea. Amelioration of cisplatininduced nephrotoxicity in rats by. Oxidative stress plays a key role in lead induced nephrotoxicity. Methotrexate is an effective anticancer and immunosuppressive agent. Paper open access gentamicin nephrotoxicity in animal.
In the present study, microarray chips were used to analyze the changes in the gene expression profile using a rat model of gentamicin. Who library cataloguing in publication data principles and methods for the assessment of nephrotoxicity associated with exposure to chemicals. Identification of genes involved in gentamicin induced nephrotoxicity. Identification of genes involved in gentamicin induced. It is a nephrotoxic antibiotic, which causes acute tubular necrosis, and its toxicity remains a major problem in clinical use. Nephrotoxicity was induced in rats by intraperitoneal injection of gentamicin at a dose of 100 mgkgday for 8 days. Altered gene expression profile in a rat model of gentamicin. In the current study a dose of 80 mgkg gentamicin was given daily to male rats for one week.
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